Post some pictures of what you have for a better answer.
2WD 2 door S10 Blazer is the closest S10 for length, track width and gas tank location.
It has been done, he already had the Blazer laying around for parts.
He moved the rear wheel well openings
before deciding to remake the center section of the frame.
So if you adjusted the S10 wheelbase to an H-body while fabbing the shorter center frame section , the rear fender mods would not be required.
S10 Drop spindles in the front and take one leaf out of the rear springs if you want it lower.
viewtopic.php?f=20&t=42946